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THE SLIDING-FILAMENT MODEL
OF MUSCULAR CONTRACTION
The contractions of vertebrate
skeletal muscle, through its pulling on bones,
are responsible for all voluntary movements. What
we generally refer to as muscle, for example the
biceps brachii, is actually the largest member
of a hierarchy of smaller and smaller organizational
units. Muscles are composed of bundles of muscle
fibers, which in turn are made of bundles
of myofibrils. Within the myofibrils are
the actual moving parts that result in contraction,
the myofilaments actin and myosin,
which are organized into contractile units called
sarcomeres.
Contraction of skeletal muscle
is initiated whan an action potential traveling
down a motor neuron reaches the neuromuscular
junction. The motor neuron releases acetylcholine,
which binds with receptors on the muscle fiber
and depolarizes the cytoplasmic membrane of the
muscle fiber. This action potential travels down
the inward-projecting T tubules that reach
deep into the muscle fiber, and actual muscular
contraction begins.
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